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Antibiotics

Antimicrobial agents for bacterial infections - mechanisms, spectrums, and resistance

BEGINNER13 Drugs

Amoxicillin-Clavulanate

Amoxicillin-Clavulanate Potassium

Penicillins (Beta-lactamase inhibitor combination)INTERMEDIATE

Use:

Bacterial infections including beta-lactamase producing organisms

Mechanism:

Amoxicillin inhibits cell wall synthesis; clavulanate inhibits beta-lactamases

โญ 15 points

Azithromycin

Azithromycin Dihydrate

MacrolidesINTERMEDIATE

Use:

Respiratory infections, STIs, atypical pneumonia

Mechanism:

Inhibits bacterial protein synthesis by binding to 50S ribosomal subunit

โญ 15 points

Cefazolin

Cefazolin

Cephalosporins (1st Generation)INTERMEDIATE

Use:

Surgical prophylaxis, skin infections, susceptible infections

Mechanism:

Inhibits bacterial cell wall synthesis

โญ 15 points

Cefepime

Cefepime

Cephalosporins (4th Generation)ADVANCED

Use:

Serious Gram-negative infections, febrile neutropenia, nosocomial pneumonia

Mechanism:

Inhibits bacterial cell wall synthesis

โญ 20 points

Cefotaxime

Cefotaxime

Cephalosporins (3rd Generation)ADVANCED

Use:

Serious infections, meningitis, gonorrhea

Mechanism:

Inhibits bacterial cell wall synthesis

โญ 20 points

Ceftaroline

Ceftaroline Fosamil

Cephalosporins (5th Generation)ADVANCED

Use:

MRSA, community-acquired pneumonia, skin infections

Mechanism:

Inhibits bacterial cell wall synthesis; high affinity for PBP2a (MRSA)

โญ 20 points

Ceftriaxone

Ceftriaxone Sodium

Cephalosporins (3rd Generation)INTERMEDIATE

Use:

Serious infections, meningitis, gonorrhea, Lyme disease

Mechanism:

Inhibits bacterial cell wall synthesis

โญ 15 points

Cefuroxime

Cefuroxime

Cephalosporins (2nd Generation)INTERMEDIATE

Use:

Respiratory infections, UTI, Lyme disease, surgical prophylaxis

Mechanism:

Inhibits bacterial cell wall synthesis

โญ 15 points

Cephalexin

Cephalexin Monohydrate

Cephalosporins (1st Generation)BEGINNER

Use:

Skin infections, streptococcal pharyngitis, UTI

Mechanism:

Inhibits bacterial cell wall synthesis by binding to PBPs

โญ 10 points

Clarithromycin

Clarithromycin

MacrolidesINTERMEDIATE

Use:

Respiratory infections, H. pylori, MAC infections

Mechanism:

Inhibits bacterial protein synthesis by binding to 50S ribosomal subunit

โญ 15 points

Levofloxacin

Levofloxacin

FluoroquinolonesINTERMEDIATE

Use:

Pneumonia, sinusitis, UTI, skin infections

Mechanism:

Inhibits bacterial DNA gyrase and topoisomerase IV

โญ 15 points

Penicillin VK

Penicillin V Potassium

PenicillinsBEGINNER

Use:

Streptococcal infections, rheumatic fever prophylaxis

Mechanism:

Inhibits bacterial cell wall synthesis

โญ 10 points

Piperacillin-Tazobactam

Piperacillin/Tazobactam

Extended-Spectrum Penicillins with Beta-Lactamase InhibitorADVANCED

Use:

Serious infections including pneumonia, intra-abdominal, sepsis

Mechanism:

Piperacillin inhibits cell wall synthesis; tazobactam inhibits beta-lactamases

โญ 20 points
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Medical Disclaimer

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