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Immunosuppressants

Drugs for transplant rejection prevention and autoimmune diseases

ADVANCED7 Drugs

Budesonide

Budesonide

Corticosteroids (Inhaled/Oral)INTERMEDIATE

Use:

Asthma, COPD, Crohn disease (oral formulation)

Mechanism:

Potent glucocorticoid with anti-inflammatory effects

15 points

Cyclosporine

Cyclosporine

Immunosuppressants (Calcineurin Inhibitors)ADVANCED

Use:

Organ transplant rejection prophylaxis, rheumatoid arthritis, psoriasis

Mechanism:

Inhibits calcineurin, blocking T-cell activation and IL-2 production

20 points

Dexamethasone

Dexamethasone

CorticosteroidsADVANCED

Use:

Severe inflammation, cerebral edema, chemotherapy-induced nausea, COVID-19

Mechanism:

Potent glucocorticoid with minimal mineralocorticoid activity

20 points

Fluticasone

Fluticasone Propionate

Corticosteroids (Inhaled/Nasal)INTERMEDIATE

Use:

Asthma, allergic rhinitis, COPD

Mechanism:

Synthetic corticosteroid with potent anti-inflammatory activity

15 points

Hydrocortisone

Hydrocortisone

CorticosteroidsINTERMEDIATE

Use:

Adrenal insufficiency, inflammation, allergic reactions, shock

Mechanism:

Binds glucocorticoid receptors; anti-inflammatory, immunosuppressive effects

15 points

Prednisone

Prednisone

CorticosteroidsINTERMEDIATE

Use:

Inflammation, autoimmune disorders, asthma, allergic reactions

Mechanism:

Binds to glucocorticoid receptors, altering gene expression

15 points

Tacrolimus

Tacrolimus

Immunosuppressants (Calcineurin Inhibitors)ADVANCED

Use:

Organ transplant rejection prophylaxis

Mechanism:

Inhibits calcineurin, preventing T-cell activation and cytokine production

20 points
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