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Epristeride
Epristeride
Use:
Benign prostatic hyperplasia,Androgenetic alopecia
Mechanism:
Inhibits type II 5-α-reductase, reducing conversion of testosterone to dihydrotestosterone
Emtricitabine
Emtricitabine
Use:
HIV-1 infection (always in combination)
Mechanism:
Cytosine analog that inhibits HIV reverse transcriptase
Enalapril
Enalapril Maleate
Use:
Hypertension, heart failure, diabetic nephropathy
Mechanism:
Inhibits ACE, preventing conversion of angiotensin I to angiotensin II
Enoxaparin
Enoxaparin
Use:
DVT/PE treatment and prophylaxis, ACS, bridge therapy
Mechanism:
Binds to antithrombin III, enhancing inactivation of Factor Xa > Factor IIa (thrombin)
Epinephrine
Epinephrine
Use:
Anaphylaxis, cardiac arrest, severe asthma/bronchospasm
Mechanism:
Non-selective alpha and beta adrenergic agonist: increases HR, BP, bronchodilation, stabilizes mast cells
Escitalopram
Escitalopram Oxalate
Use:
Depression, generalized anxiety disorder
Mechanism:
S-enantiomer of citalopram; selective serotonin reuptake inhibitor
Eszopiclone
Eszopiclone
Use:
Insomnia
Mechanism:
Binds to GABA-A receptor (preferentially at alpha-1 subunit)
Ethinyl Estradiol/Norethindrone
Ethinyl Estradiol/Norethindrone
Use:
Birth control, acne, dysmenorrhea, endometriosis
Mechanism:
Estrogen + progestin suppress ovulation, thicken cervical mucus, thin endometrium
Ezetimibe
Ezetimibe
Use:
Primary hyperlipidemia, homozygous familial hypercholesterolemia (adjunct to statin)
Mechanism:
Inhibits cholesterol absorption at brush border of small intestine via NPC1L1 transporter
Efavirenz
Efavirenz
Use:
HIV-1 infection (part of combination therapy)
Mechanism:
Non-competitive inhibition of HIV-1 reverse transcriptase
Empagliflozin
Empagliflozin
Use:
Type 2 diabetes, heart failure, cardiovascular risk reduction, chronic kidney disease
Mechanism:
Inhibits SGLT2 in proximal renal tubule, reducing glucose reabsorption
Emtricitabine/Tenofovir
Emtricitabine/Tenofovir Disoproxil Fumarate
Use:
HIV treatment (part of cART), HIV PrEP
Mechanism:
NRTIs: competitively inhibit HIV reverse transcriptase and terminate viral DNA chain
Enzalutamide
Enzalutamide
Use:
Metastatic castration-resistant prostate cancer
Mechanism:
Competitive androgen receptor antagonist; prevents nuclear translocation and DNA binding
Epinephrine IV
Epinephrine
Use:
Cardiac arrest, anaphylaxis, shock
Mechanism:
Non-selective alpha and beta agonist: vasoconstriction (alpha), increased inotropy/chronotropy (beta-1), bronchodilation (beta-2)
Erlotinib
Erlotinib
Use:
Non-small cell lung cancer (NSCLC), pancreatic cancer
Mechanism:
Inhibits epidermal growth factor receptor (EGFR) tyrosine kinase
Ertapenem
Ertapenem
Use:
Complicated intra-abdominal, skin, urinary tract infections, pneumonia
Mechanism:
Inhibits bacterial cell wall synthesis by binding to PBPs
Etanercept
Etanercept
Use:
Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, plaque psoriasis
Mechanism:
Soluble TNF receptor fusion protein that binds TNF-alpha and TNF-beta
Ethambutol
Ethambutol
Use:
Tuberculosis
Mechanism:
Inhibits arabinosyl transferase, disrupts mycobacterial cell wall synthesis
Etonogestrel Implant
Etonogestrel
Use:
Long-acting reversible contraception
Mechanism:
Progestin-only contraception: suppresses ovulation, thickens cervical mucus, thins endometrium
Etoposide
Etoposide
Use:
Testicular cancer, small cell lung cancer, lymphomas, leukemias
Mechanism:
Inhibits topoisomerase II, causing DNA strand breaks
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