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Pantoprazole
Pantoprazole Sodium
Use:
GERD, erosive esophagitis, peptic ulcer disease
Mechanism:
Irreversibly inhibits H+/K+ ATPase in gastric parietal cells
Penicillin VK
Penicillin V Potassium
Use:
Streptococcal infections, rheumatic fever prophylaxis
Mechanism:
Inhibits bacterial cell wall synthesis
Perindopril
Perindopril
Use:
Hypertension, Heart failure, Post-myocardial infarction, Diabetic nephropathy
Mechanism:
Inhibits angiotensin-converting enzyme, reducing conversion of angiotensin I to angiotensin II, leading to vasodilation, decreased aldosterone secretion, and lowered blood pressure.
Paroxetine
Paroxetine Hydrochloride
Use:
Depression, anxiety disorders, OCD, PTSD, PMDD
Mechanism:
Potent selective serotonin reuptake inhibitor
Pramipexole
Pramipexole
Use:
Parkinson's disease and restless legs syndrome (RLS)
Mechanism:
Non-ergot dopamine agonist with preferential activity at D2/D3 receptors
Pravastatin
Pravastatin
Use:
Hyperlipidemia, cardiovascular disease prevention
Mechanism:
Competitively inhibits HMG-CoA reductase, reducing cholesterol synthesis
Prednisone
Prednisone
Use:
Inflammation, autoimmune disorders, asthma, allergic reactions
Mechanism:
Binds to glucocorticoid receptors, altering gene expression
Propranolol
Propranolol Hydrochloride
Use:
Hypertension, angina, arrhythmias, migraine prophylaxis, tremor
Mechanism:
Non-selective beta-1 and beta-2 adrenergic receptor antagonist
Paclitaxel
Paclitaxel
Use:
Breast, ovarian, lung cancers, Kaposi sarcoma
Mechanism:
Stabilizes microtubules, preventing depolymerization, inhibiting mitosis
Pegfilgrastim
Pegfilgrastim
Use:
Chemotherapy-induced neutropenia prophylaxis
Mechanism:
Pegylated G-CSF that stimulates neutrophil production with prolonged duration
Pembrolizumab
Pembrolizumab
Use:
Melanoma, NSCLC, head/neck, bladder, MSI-H tumors
Mechanism:
Blocks PD-1 receptor, enhancing T-cell mediated immune response against tumors
Pemetrexed
Pemetrexed
Use:
Non-squamous NSCLC, mesothelioma
Mechanism:
Inhibits multiple folate-dependent enzymes (thymidylate synthase, DHFR, GARFT)
Phenobarbital
Phenobarbital
Use:
Seizures, status epilepticus, sedation
Mechanism:
Enhances GABA-A receptor activity, prolongs chloride channel opening
Phenylephrine IV
Phenylephrine
Use:
Hypotension (anesthesia, shock), nasal decongestant
Mechanism:
Selective alpha-1 agonist causing vasoconstriction
Phenytoin
Phenytoin
Use:
Seizures, status epilepticus, arrhythmias
Mechanism:
Blocks voltage-gated sodium channels, stabilizes neuronal membranes
Piperacillin-Tazobactam
Piperacillin/Tazobactam
Use:
Serious infections including pneumonia, intra-abdominal, sepsis
Mechanism:
Piperacillin inhibits cell wall synthesis; tazobactam inhibits beta-lactamases
Posaconazole
Posaconazole
Use:
Invasive fungal infection prophylaxis, aspergillosis, mucormycosis
Mechanism:
Inhibits fungal CYP450 14-alpha-demethylase, disrupts ergosterol synthesis
Procainamide
Procainamide
Use:
Ventricular arrhythmias, atrial fibrillation, PSVT
Mechanism:
Blocks sodium channels, prolongs action potential duration and refractory period
Propofol
Propofol
Use:
Induction and maintenance of anesthesia, procedural sedation, ICU sedation
Mechanism:
Enhances GABA-A receptor activity, causes CNS depression
Propylthiouracil
Propylthiouracil
Use:
Hyperthyroidism (first trimester pregnancy, thyroid storm)
Mechanism:
Inhibits thyroid peroxidase AND peripheral conversion of T4 to T3
Pyrazinamide
Pyrazinamide
Use:
Tuberculosis
Mechanism:
Converted to pyrazinoic acid in acidic environment, disrupts mycobacterial membrane
Medical Disclaimer
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