Pharmacology Library
Your comprehensive reference for drug classifications, mechanisms, and clinical pearls.
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Naproxen
Naproxen Sodium
Use:
Pain, inflammation, fever, arthritis, dysmenorrhea
Mechanism:
Non-selective COX-1 and COX-2 inhibitor reducing prostaglandin synthesis
Naloxone
Naloxone
Use:
Emergency treatment of known or suspected opioid overdose
Mechanism:
Competitive antagonist at mu, kappa, and delta opioid receptors
Nifedipine
Nifedipine
Use:
Hypertension, angina, Raynaud phenomenon
Mechanism:
Dihydropyridine CCB; selective for vascular smooth muscle
Nitrofurantoin
Nitrofurantoin
Use:
Uncomplicated UTI treatment and prophylaxis
Mechanism:
Damages bacterial DNA via reactive intermediates
Nitroglycerin
Nitroglycerin
Use:
Angina pectoris (acute and prophylaxis), heart failure
Mechanism:
Converted to nitric oxide, activates guanylate cyclase, increases cGMP causing vasodilation (venous > arterial)
Neostigmine
Neostigmine
Use:
Reversal of non-depolarizing neuromuscular blockade, myasthenia gravis
Mechanism:
Reversible acetylcholinesterase inhibitor: increases acetylcholine at neuromuscular junction
Nivolumab
Nivolumab
Use:
Melanoma, NSCLC, renal cell carcinoma, head/neck, bladder cancers
Mechanism:
Blocks PD-1 receptor on T-cells, preventing tumor immune evasion
Norepinephrine
Norepinephrine Bitartrate
Use:
Shock, severe hypotension
Mechanism:
Potent alpha-1 agonist (vasoconstriction) with beta-1 effects (increased inotropy)
Nortriptyline
Nortriptyline Hydrochloride
Use:
Depression, neuropathic pain, smoking cessation
Mechanism:
Inhibits norepinephrine and serotonin reuptake; less anticholinergic than amitriptyline
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