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Lansoprazole
Lansoprazole
Use:
GERD, peptic ulcer disease, H. pylori eradication, Zollinger-Ellison syndrome
Mechanism:
Irreversibly inhibits H+/K+-ATPase (proton pump) in gastric parietal cells
Lacosamide
Lacosamide
Use:
Focal seizures
Mechanism:
Enhances slow inactivation of voltage-gated sodium channels
Latanoprost
Latanoprost
Use:
Open-angle glaucoma, ocular hypertension
Mechanism:
Increases uveoscleral outflow of aqueous humor
Levetiracetam
Levetiracetam
Use:
Partial-onset seizures, myoclonic seizures, generalized tonic-clonic seizures
Mechanism:
Binds to synaptic vesicle protein SV2A, modulates neurotransmitter release
Levofloxacin
Levofloxacin
Use:
Pneumonia, sinusitis, UTI, skin infections
Mechanism:
Inhibits bacterial DNA gyrase and topoisomerase IV
Levonorgestrel
Levonorgestrel
Use:
Emergency contraception, long-acting contraception (IUD), hormone therapy
Mechanism:
Progestin that prevents ovulation, thickens cervical mucus, thins endometrium
Levothyroxine
Levothyroxine Sodium
Use:
Hypothyroidism, thyroid hormone replacement
Mechanism:
Synthetic T4 that converts to T3, regulating metabolism
Lisinopril
Lisinopril
Use:
Hypertension, heart failure, post-MI
Mechanism:
Inhibits angiotensin-converting enzyme, reducing angiotensin II formation
Lorazepam
Lorazepam
Use:
Anxiety, insomnia, seizures, sedation
Mechanism:
Enhances GABAergic neurotransmission via benzodiazepine receptors
Losartan
Losartan Potassium
Use:
Hypertension, diabetic nephropathy, heart failure, stroke prevention
Mechanism:
Selective AT1 receptor antagonist, blocking angiotensin II effects
Lamotrigine
Lamotrigine
Use:
Seizures, bipolar disorder
Mechanism:
Blocks voltage-gated sodium channels and inhibits glutamate release
Lenalidomide
Lenalidomide
Use:
Multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma
Mechanism:
Multiple mechanisms: immunomodulation, anti-angiogenesis, direct cytotoxicity
Letrozole
Letrozole
Use:
Hormone receptor-positive breast cancer (postmenopausal)
Mechanism:
Inhibits aromatase enzyme, blocking estrogen synthesis
Levodopa-Carbidopa
Levodopa/Carbidopa
Use:
Treatment of Parkinson's disease and parkinsonism
Mechanism:
Levodopa crosses BBB and converts to dopamine; carbidopa inhibits peripheral decarboxylase, increasing CNS levodopa availability
Linezolid
Linezolid
Use:
VRE, MRSA, pneumonia, skin infections
Mechanism:
Inhibits bacterial protein synthesis by binding to 23S ribosomal RNA of 50S subunit
Liraglutide
Liraglutide
Use:
Type 2 diabetes, obesity, cardiovascular risk reduction
Mechanism:
GLP-1 receptor agonist increasing insulin and decreasing glucagon secretion
Lithium
Lithium Carbonate
Use:
Bipolar disorder, mania, depression prophylaxis
Mechanism:
Alters sodium transport in nerve and muscle cells; affects neurotransmitter reuptake
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